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Digoxin, an Overlooked Agonist of RORγ/RORγT

Digoxin was one of the first identified RORγT receptor inverse agonists inhibiting the differentiation of Th17 cells. However, this compound exhibits inhibitory activity at relatively high concentrations that mediate cytotoxic effects. We previously identified several cardenolides that are structura...

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書目詳細資料
發表在:Front Pharmacol
Main Authors: Karaś, Kaja, Sałkowska, Anna, Sobalska-Kwapis, Marta, Walczak-Drzewiecka, Aurelia, Strapagiel, Dominik, Dastych, Jarosław, Bachorz, Rafał A., Ratajewski, Marcin
格式: Artigo
語言:Inglês
出版: Frontiers Media S.A. 2019
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6330298/
https://ncbi.nlm.nih.gov/pubmed/30666196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2018.01460
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