Digoxin, an Overlooked Agonist of RORγ/RORγT

Digoxin was one of the first identified RORγT receptor inverse agonists inhibiting the differentiation of Th17 cells. However, this compound exhibits inhibitory activity at relatively high concentrations that mediate cytotoxic effects. We previously identified several cardenolides that are structura...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Front Pharmacol
Egile Nagusiak: Karaś, Kaja, Sałkowska, Anna, Sobalska-Kwapis, Marta, Walczak-Drzewiecka, Aurelia, Strapagiel, Dominik, Dastych, Jarosław, Bachorz, Rafał A., Ratajewski, Marcin
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Frontiers Media S.A. 2019
Gaiak:
Pharmacology
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6330298/
https://ncbi.nlm.nih.gov/pubmed/30666196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2018.01460
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