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Molecular Mechanism of Action of RORγt Agonists and Inverse Agonists: Insights from Molecular Dynamics Simulation

As an attractive drug-target, retinoic acid receptor-related orphan receptor-gamma-t (RORγt) has been employed widely to develop clinically relevant small molecular modulators as potent therapy for autoimmune disease and cancer, but its molecular mechanism of action (MOA) remains unclear. In the pre...

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Detalhes bibliográficos
Publicado no:Molecules
Main Authors: Sun, Nannan, Yuan, Congmin, Ma, Xiaojun, Wang, Yonghui, Gu, Xianfeng, Fu, Wei
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6321388/
https://ncbi.nlm.nih.gov/pubmed/30513894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules23123181
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