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Molecular Mechanism of Action of RORγt Agonists and Inverse Agonists: Insights from Molecular Dynamics Simulation

As an attractive drug-target, retinoic acid receptor-related orphan receptor-gamma-t (RORγt) has been employed widely to develop clinically relevant small molecular modulators as potent therapy for autoimmune disease and cancer, but its molecular mechanism of action (MOA) remains unclear. In the pre...

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Опубликовано в: :Molecules
Главные авторы: Sun, Nannan, Yuan, Congmin, Ma, Xiaojun, Wang, Yonghui, Gu, Xianfeng, Fu, Wei
Формат: Artigo
Язык:Inglês
Опубликовано: MDPI 2018
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6321388/
https://ncbi.nlm.nih.gov/pubmed/30513894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules23123181
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