Bitopic Sphingosine 1-Phosphate Receptor 3 (S1P3) Antagonist Rescue from Complete Heart Block: Pharmacological and Genetic Evidence for Direct S1P3 Regulation of Mouse Cardiac Conduction

The molecular pharmacology of the G protein–coupled receptors for sphingosine 1-phosphate (S1P) provides important insight into established and new therapeutic targets. A new, potent bitopic S1P(3) antagonist, SPM-354, with in vivo activity, has been used, together with S1P(3)-knockin and S1P(3)-kno...

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Detaylı Bibliyografya
Yayımlandı:Mol Pharmacol
Asıl Yazarlar: Sanna, M. Germana, Vincent, Kevin P., Repetto, Emanuela, Nguyen, Nhan, Brown, Steven J., Abgaryan, Lusine, Riley, Sean W., Leaf, Nora B., Cahalan, Stuart M., Kiosses, William B., Kohno, Yasushi, Brown, Joan Heller, McCulloch, Andrew D., Rosen, Hugh, Gonzalez-Cabrera, Pedro J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The American Society for Pharmacology and Experimental Therapeutics 2016
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Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4702096/
https://ncbi.nlm.nih.gov/pubmed/26494861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.115.100222
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