Sphingosine 1-Phosphate Receptor 1 (S1P(1)) Upregulation and Amelioration of Experimental Autoimmune Encephalomyelitis by an S1P(1) Antagonist

Sphingosine 1-phosphate receptor 1 (S1P(1)) is a G protein–coupled receptor that is critical for proper lymphocyte development and recirculation. Agonists to S1P(1) are currently in use clinically for the treatment of multiple sclerosis, and these drugs may act on both S1P(1) expressed on lymphocyte...

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Autors principals: Cahalan, Stuart M., Gonzalez-Cabrera, Pedro J., Nguyen, Nhan, Guerrero, Miguel, Cisar, Elizabeth A. George, Leaf, Nora B., Brown, Steven J., Roberts, Edward, Rosen, Hugh
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Pharmacology and Experimental Therapeutics 2013
Matèries:
Accelerated Communication
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3558813/
https://ncbi.nlm.nih.gov/pubmed/23204443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.112.082958
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