S1P(1) Receptor Modulation with Cyclical Recovery from Lymphopenia Ameliorates Mouse Model of Multiple Sclerosis

Multiple sclerosis (MS) therapies modulate T-cell autoimmunity in the central nervous system (CNS) but may exacerbate latent infections. Fingolimod, a nonselective sphingosine-1-phosphate (S1P) receptor agonist that induces sustained lymphopenia and accumulates in the CNS, represents a new treatment...

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Bibliografiska uppgifter
Huvudupphovsmän: Gonzalez-Cabrera, Pedro J., Cahalan, Stuart M., Nguyen, Nhan, Sarkisyan, Gor, Leaf, Nora B., Cameron, Michael D., Kago, Tomoyuki, Rosen, Hugh
Materialtyp: Artigo
Språk:Inglês
Publicerad: The American Society for Pharmacology and Experimental Therapeutics 2012
Ämnen:
Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3263953/
https://ncbi.nlm.nih.gov/pubmed/22031473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.111.076109
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