DAGLβ Inhibition Perturbs a Lipid Network Involved in Macrophage Inflammatory Responses

Por Hsu, Ku-Lung, Tsuboi, Katsunori, Adibekian, Alexander, Pugh, Holly, Masuda, Kim, Cravatt, Benjamin F.
Publicado em 2012

Combined inhibition of FAAH and COX produces enhanced anti-allodynic effects in mouse neuropathic and inflammatory pain models

Por Grim, Travis W., Ghosh, Sudeshna, Hsu, Ku-Lung, Cravatt, Benjamin F., Kinsey, Steven G., Lichtman, Aron H.
Publicado em 2014

Development and Optimization of Piperidyl-1,2,3-Triazole Ureas as Selective Chemical Probes of Endocannabinoid Biosynthesis

Por Hsu, Ku-Lung, Tsuboi, Katsunori, Whitby, Landon R., Speers, Anna E., Pugh, Holly, Inloes, Jordon, Cravatt, Benjamin F.
Publicado em 2013

Identification of the Major Prostaglandin Glycerol Ester Hydrolase in Human Cancer Cells

Por Manna, Joseph D., Wepy, James A., Hsu, Ku-Lung, Chang, Jae Won, Cravatt, Benjamin F., Marnett, Lawrence J.
Publicado no J Biol Chem (2014)

Discovery and Optimization of Piperidyl-1,2,3-Triazole Ureas as Potent, Selective, and In Vivo-Active Inhibitors of Alpha/Beta-Hydrolase Domain Containing 6 (ABHD6)

Por Hsu, Ku-Lung, Tsuboi, Katsunori, Chang, Jae Won, Whitby, Landon R., Speers, Anna E., Pugh, Holly, Cravatt, Benjamin F.
Publicado em 2013

Click-generated triazole ureas as ultrapotent, in vivo-active serine hydrolase inhibitors

Por Adibekian, Alexander, Martin, Brent R., Wang, Chu, Hsu, Ku-Lung, Bachovchin, Daniel A., Niessen, Sherry, Hoover, Heather, Cravatt, Benjamin F.
Publicado em 2011

The hereditary spastic paraplegia-related enzyme DDHD2 is a principal brain triglyceride lipase

Por Inloes, Jordon M., Hsu, Ku-Lung, Dix, Melissa M., Viader, Andreu, Masuda, Kim, Takei, Thais, Wood, Malcolm R., Cravatt, Benjamin F.
Publicado em 2014

Serine Hydrolase Inhibitors Block Necrotic Cell Death by Preventing Calcium Overload of the Mitochondria and Permeability Transition Pore Formation

Por Yun, Bogeon, Lee, HeeJung, Ghosh, Moumita, Cravatt, Benjamin F., Hsu, Ku-Lung, Bonventre, Joseph V., Ewing, Heather, Gelb, Michael H., Leslie, Christina C.
Publicado em 2014

Activity-Based Protein Profiling of Oncogene-Driven Changes in Metabolism Reveals Broad Dysregulation of PAFAH1B2 and 1B3 in Cancer

Por Kohnz, Rebecca A., Mulvihill, Melinda M., Chang, Jae Won, Hsu, Ku-Lung, Sorrentino, Antonio, Cravatt, Benjamin F., Bandyopadhyay, Sourav, Goga, Andrei, Nomura, Daniel K.
Publicado no ACS Chem Biol (2015)

Mapping posttranscriptional regulation of the human glycome uncovers microRNA defining the glycocode

Por Agrawal, Praveen, Kurcon, Tomasz, Pilobello, Kanoelani T., Rakus, John F., Koppolu, Sujeethraj, Liu, Zhongyin, Batista, Bianca S., Eng, William S., Hsu, Ku-Lung, Liang, Yaxuan, Mahal, Lara K.
Publicado em 2014

Competitive Activity-Based Protein Profiling Identifies Aza-β-Lactams as a Versatile Chemotype for Serine Hydrolase Inhibition

Por Zuhl, Andrea M., Mohr, Justin T., Bachovchin, Daniel A., Niessen, Sherry, Hsu, Ku-Lung, Berlin, Jacob M., Dochnahl, Maximilian, López-Alberca, María P., Fu, Gregory C., Cravatt, Benjamin F.
Publicado em 2012

Diacylglycerol lipase disinhibits VTA dopamine neurons during chronic nicotine exposure

Por Buczynski, Matthew W., Herman, Melissa A., Hsu, Ku-Lung, Natividad, Luis A., Irimia, Cristina, Polis, Ilham Y., Pugh, Holly, Chang, Jae Won, Niphakis, Micah J., Cravatt, Benjamin F., Roberto, Marisa, Parsons, Loren H.
Publicado no Proc Natl Acad Sci U S A (2016)

Confirming Target Engagement for Reversible Inhibitors In Vivo by Kinetically Tuned Activity-Based Probes

Por Adibekian, Alexander, Martin, Brent R., Chang, Jae Won, Hsu, Ku-Lung, Tsuboi, Katsunori, Bachovchin, Daniel A., Speers, Anna E., Brown, Steven J., Spicer, Timothy, Fernandez-Vega, Virneliz, Ferguson, Jill, Hodder, Peter S., Rosen, Hugh, Cravatt, Benjamin F.
Publicado em 2012

Selective inhibitors and tailored activity probes for lipoprotein-associated phospholipase A(2)

Por Nagano, Joseph M. G., Hsu, Ku-Lung, Whitby, Landon R., Niphakis, Micah J., Speers, Anna E., Brown, Steven J., Spicer, Timothy, Fernandez-Vega, Virneliz, Ferguson, Jill, Hodder, Peter, Srinivasan, Prabhavathi, Gonzalez, Tara D., Rosen, Hugh, Bahnson, Brian J., Cravatt, Benjamin F.
Publicado em 2012

Integrated phenotypic and activity-based profiling links Ces3 to obesity and diabetes

Por Dominguez, Eduardo, Galmozzi, Andrea, Chang, Jae Won, Hsu, Ku-Lung, Pawlak, Joanna, Li, Weiwei, Godio, Cristina, Thomas, Jason, Partida, David, Niessen, Sherry, O'Brien, Paul E., Russell, Aaron P., Watt, Matthew J., Nomura, Daniel K., Cravatt, Benjamin F., Saez, Enrique
Publicado em 2013

ABHD6 blockade exerts antiepileptic activity in PTZ-induced seizures and in spontaneous seizures in R6/2 mice

Por Naydenov, Alipi V., Horne, Eric A., Cheah, Christine S., Swinney, Katie, Hsu, Ku-Lung, Cao, Jessica K., Marrs, William, Blankman, Jacqueline L., Tu, Sarah, Cherry, Allison E., Fung, Susan, Wen, Andy, Li, Weiwei, Saporito, Michael S., Selley, Dana E., Cravatt, Benjamin F., Oakley, John C., Stella, Nephi
Publicado em 2014

A selective inhibitor of platelet-activating factor acetylhydrolases 1b2 and 1b3 that impairs cancer cell survival

Por Chang, Jae Won, Zuhl, Andrea M., Speers, Anna E., Niessen, Sherry, Brown, Steven J., Mulvihill, Melinda M., Fan, Yi Chiao, Spicer, Timothy P., Southern, Mark, Scampavia, Louis, Fernandez-Vega, Virneliz, Dix, Melissa M., Cameron, Michael D., Hodder, Peter S., Rosen, Hugh, Nomura, Daniel K., Kwon, Ohyun, Hsu, Ku-Lung, Cravatt, Benjamin F.
Publicado no ACS Chem Biol (2015)

A highly selective, reversible inhibitor identified by comparative chemoproteomics modulates diacylglycerol lipase activity in neurons

Por Baggelaar, Marc P., Chameau, Pascal J. P., Kantae, Vasudev, Hummel, Jessica, Hsu, Ku-Lung, Janssen, Freek, van der Wel, Tom, Soethoudt, Marjolein, Deng, Hui, den Dulk, Hans, Allarà, Marco, Florea, Bogdan I., Di Marzo, Vincenzo, Wadman, Wytse J., Kruse, Chris G., Overkleeft, Herman S., Hankemeier, Thomas, Werkman, Taco R., Cravatt, Benjamin F., van der Stelt, Mario
Publicado no J Am Chem Soc (2015)