ABHD6 blockade exerts antiepileptic activity in PTZ-induced seizures and in spontaneous seizures in R6/2 mice

The serine hydrolase α/β-hydrolase domain 6 (ABHD6) hydrolyzes the most abundant endocannabinoid (eCB) in the brain, 2-arachidonoylglycerol (2-AG), and controls its availability at cannabinoid receptors. We show that ABHD6 inhibition decreases pentylenetetrazole (PTZ)-induced generalized tonic-cloni...

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Detalhes bibliográficos
Main Authors: Naydenov, Alipi V., Horne, Eric A., Cheah, Christine S., Swinney, Katie, Hsu, Ku-Lung, Cao, Jessica K., Marrs, William, Blankman, Jacqueline L., Tu, Sarah, Cherry, Allison E., Fung, Susan, Wen, Andy, Li, Weiwei, Saporito, Michael S., Selley, Dana E., Cravatt, Benjamin F., Oakley, John C., Stella, Nephi
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4136499/
https://ncbi.nlm.nih.gov/pubmed/25033180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2014.06.030
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