ABHD6 blockade exerts antiepileptic activity in PTZ-induced seizures and in spontaneous seizures in R6/2 mice

The serine hydrolase α/β-hydrolase domain 6 (ABHD6) hydrolyzes the most abundant endocannabinoid (eCB) in the brain, 2-arachidonoylglycerol (2-AG), and controls its availability at cannabinoid receptors. We show that ABHD6 inhibition decreases pentylenetetrazole (PTZ)-induced generalized tonic-cloni...

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Main Authors: Naydenov, Alipi V., Horne, Eric A., Cheah, Christine S., Swinney, Katie, Hsu, Ku-Lung, Cao, Jessica K., Marrs, William, Blankman, Jacqueline L., Tu, Sarah, Cherry, Allison E., Fung, Susan, Wen, Andy, Li, Weiwei, Saporito, Michael S., Selley, Dana E., Cravatt, Benjamin F., Oakley, John C., Stella, Nephi
Format: Artigo
Sprog:Inglês
Udgivet: 2014
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4136499/
https://ncbi.nlm.nih.gov/pubmed/25033180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2014.06.030
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