The Pharmacological Landscape and Therapeutic Potential of Serine Hydrolases

Por Bachovchin, Daniel A., Cravatt, Benjamin F.
Publicado em 2012

Pyroptosis and apoptosis pathways engage in bidirectional crosstalk in monocytes and macrophages

Por Taabazuing, Cornelius Y., Okondo, Marian C., Bachovchin, Daniel A.
Publicado no Cell Chem Biol (2017)

The NLRP1 and CARD8 inflammasomes

Por Taabazuing, Cornelius Y., Griswold, Andrew R., Bachovchin, Daniel A.
Publicado no Immunol Rev (2020)

Substrate-Free High-Throughput Screening Identifies Selective Inhibitors for Uncharacterized Enzymes

Por Bachovchin, Daniel A., Brown, Steven J., Rosen, Hugh, Cravatt, Benjamin F.
Publicado em 2009

α-Lytic protease can exist in two separately stable conformations with different His(57) mobilities and catalytic activities

Por Haddad, Kristin Coffman, Sudmeier, James L., Bachovchin, Daniel A., Bachovchin, William W.
Publicado em 2005

Rapid Development of a Potent Photo-Triggered Inhibitor of the Serine Hydrolase RBBP9

Por Liu, Xiaodan, Dix, Melissa, Speers, Anna E., Bachovchin, Daniel A., Zuhl, Andrea M., Cravatt, Benjamin F., Kodadek, Thomas
Publicado em 2012

Click-generated triazole ureas as ultrapotent, in vivo-active serine hydrolase inhibitors

Por Adibekian, Alexander, Martin, Brent R., Wang, Chu, Hsu, Ku-Lung, Bachovchin, Daniel A., Niessen, Sherry, Hoover, Heather, Cravatt, Benjamin F.
Publicado em 2011

DPP8/9 inhibitors are universal activators of functional NLRP1 alleles

Por Gai, Kuo, Okondo, Marian C., Rao, Sahana D., Chui, Ashley J., Ball, Daniel P., Johnson, Darren C., Bachovchin, Daniel A.
Publicado no Cell Death Dis (2019)

DPP9’s Enzymatic Activity and Not Its Binding to CARD8 Inhibits Inflammasome Activation

Por Griswold, Andrew R., Ball, Daniel P., Bhattacharjee, Abir, Chui, Ashley J., Rao, Sahana D., Taabazuing, Cornelius Y., Bachovchin, Daniel A.
Publicado no ACS Chem Biol (2019)

Potent and Selective Inhibitors of Glutathione S-transferase Omega 1 that Impair Cancer Drug Resistance

Por Tsuboi, Katsunori, Bachovchin, Daniel A., Speers, Anna E., Spicer, Timothy P., Fernandez-Vega, Virneliz, Hodder, Peter, Rosen, Hugh, Cravatt, Benjamin F.
Publicado em 2011

Novel Inhibitors for PRMT1 Discovered by High–Throughput Screening Using Activity–Based Fluorescence Polarization

Por Dillon, Myles B. C., Bachovchin, Daniel A., Brown, Steven J., Finn, M.G., Rosen, Hugh, Cravatt, Benjamin F., Mowen, Kerri A.
Publicado em 2012

Inhibition of Dpp8/9 Activates the Nlrp1b Inflammasome

Por Okondo, Marian C., Rao, Sahana D., Taabazuing, Cornelius Y., Chui, Ashley J., Poplawski, Sarah E., Johnson, Darren C., Bachovchin, Daniel A.
Publicado no Cell Chem Biol (2018)

DPP8/9 inhibitors activate the CARD8 inflammasome in resting lymphocytes

Por Johnson, Darren C., Okondo, Marian C., Orth, Elizabeth L., Rao, Sahana D., Huang, Hsin-Che, Ball, Daniel P., Bachovchin, Daniel A.
Publicado no Cell Death Dis (2020)

Superfamily-wide portrait of serine hydrolase inhibition achieved by library-versus-library screening

Por Bachovchin, Daniel A., Ji, Tianyang, Li, Weiwei, Simon, Gabriel M., Blankman, Jacqueline L., Adibekian, Alexander, Hoover, Heather, Niessen, Sherry, Cravatt, Benjamin F.
Publicado em 2010

Discovery and Optimization of Sulfonyl Acrylonitriles as Selective, Covalent Inhibitors of Protein Phosphatase Methylesterase-1

Por Bachovchin, Daniel A., Zuhl, Andrea M., Speers, Anna E., Wolfe, Monique R., Weerapana, Eranthie, Brown, Steven J., Rosen, Hugh, Cravatt, Benjamin F.
Publicado em 2011

A chemical strategy for protease substrate profiling

Por Griswold, Andrew R., Cifani, Paolo, Rao, Sahana D., Axelrod, Abram J., Miele, Matthew M., Hendrickson, Ronald C., Kentsis, Alex, Bachovchin, Daniel A.
Publicado no Cell Chem Biol (2019)

A Fluopol-ABPP HTS Assay to Identify PAD Inhibitors

Por Knuckley, Bryan, Jones, Justin E., Bachovchin, Daniel A., Slack, Jessica, Causey, Corey P., Brown, Steven J., Rosen, Hugh, Cravatt, Benjamin F., Thompson, Paul R.
Publicado em 2010

Quantitative reactivity profiling predicts functional cysteines in proteomes

Por Weerapana, Eranthie, Wang, Chu, Simon, Gabriel M., Richter, Florian, Khare, Sagar, Dillon, Myles B.D., Bachovchin, Daniel A., Mowen, Kerri, Baker, David, Cravatt, Benjamin F.
Publicado em 2010

Oxime esters as selective, covalent inhibitors of the serine hydrolase retinoblastoma-binding protein 9 (RBBP9)

Por Bachovchin, Daniel A., Wolfe, Monique R., Masuda, Kim, Brown, Steven J., Spicer, Timothy P., Fernandez-Vega, Virneliz, Chase, Peter, Hodder, Peter S., Rosen, Hugh, Cravatt, Benjamin F.
Publicado em 2010

Activation of the CARD8 Inflammasome Requires a Disordered Region

Por Chui, Ashley J., Griswold, Andrew R., Taabazuing, Cornelius Y., Orth, Elizabeth L., Gai, Kuo, Rao, Sahana D., Ball, Daniel P., Hsiao, Jeffrey C., Bachovchin, Daniel A.
Publicado no Cell Rep (2020)