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Rapid Development of a Potent Photo-Triggered Inhibitor of the Serine Hydrolase RBBP9

The serine hydrolases constitute a large class of enzymes that play important roles in physiology. There is great interest in the development of potent and selective pharmacological inhibitors to these proteins. Traditional active site inhibitors often have limited selectivity within this superfamil...

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Detalhes bibliográficos
Main Authors: Liu, Xiaodan, Dix, Melissa, Speers, Anna E., Bachovchin, Daniel A., Zuhl, Andrea M., Cravatt, Benjamin F., Kodadek, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3777423/
https://ncbi.nlm.nih.gov/pubmed/22907802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201200445
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