Pyroptosis and apoptosis pathways engage in bidirectional crosstalk in monocytes and macrophages

by Taabazuing, Cornelius Y., Okondo, Marian C., Bachovchin, Daniel A.
Published in Cell Chem Biol (2017)

DPP8/9 inhibitors are universal activators of functional NLRP1 alleles

by Gai, Kuo, Okondo, Marian C., Rao, Sahana D., Chui, Ashley J., Ball, Daniel P., Johnson, Darren C., Bachovchin, Daniel A.
Published in Cell Death Dis (2019)

Inhibition of Dpp8/9 Activates the Nlrp1b Inflammasome

by Okondo, Marian C., Rao, Sahana D., Taabazuing, Cornelius Y., Chui, Ashley J., Poplawski, Sarah E., Johnson, Darren C., Bachovchin, Daniel A.
Published in Cell Chem Biol (2018)

DPP8/9 inhibitors activate the CARD8 inflammasome in resting lymphocytes

by Johnson, Darren C., Okondo, Marian C., Orth, Elizabeth L., Rao, Sahana D., Huang, Hsin-Che, Ball, Daniel P., Bachovchin, Daniel A.
Published in Cell Death Dis (2020)

DPP8/9 inhibitor-induced pyroptosis for treatment of acute myeloid leukemia

by Johnson, Darren C., Taabazuing, Cornelius Y., Okondo, Marian C., Chui, Ashley J., Rao, Sahana D., Brown, Fiona C., Reed, Casie, Peguero, Elizabeth, de Stanchina, Elisa, Kentsis, Alex, Bachovchin, Daniel A.
Published in Nat Med (2018)

N-terminal degradation activates the NLRP1B inflammasome

by Chui, Ashley J., Okondo, Marian C., Rao, Sahana D., Gai, Kuo, Griswold, Andrew R., Johnson, Darren C., Ball, Daniel P., Taabazuing, Cornelius Y., Orth, Elizabeth L., Vittimberga, Brooke A., Bachovchin, Daniel A.
Published in Science (2019)

LACTB is a tumour suppressor that modulates lipid metabolism and cell state

by Keckesova, Zuzana, Donaher, Joana Liu, De Cock, Jasmine, Freinkman, Elizaveta, Lingrell, Susanne, Bachovchin, Daniel A., Bierie, Brian, Tischler, Verena, Noske, Aurelia, Okondo, Marian C., Reinhardt, Ferenc, Thiru, Prathapan, Golub, Todd R., Vance, Jean E., Weinberg, Robert A.
Published in Nature (2017)

DPP8/9 inhibition induces pro-caspase-1-dependent monocyte and macrophage pyroptosis

by Okondo, Marian C., Johnson, Darren C., Sridharan, Ramya, Go, Eun Bin, Chui, Ashley J., Wang, Mitchell S., Poplawski, Sarah E., Wu, Wengen, Liu, Yuxin, Lai, Jack H., Sanford, David G., Arciprete, Michael O., Golub, Todd R., Bachovchin, William W., Bachovchin, Daniel A.
Published in Nat Chem Biol (2016)