DPP8/9 inhibition induces pro-caspase-1-dependent monocyte and macrophage pyroptosis

Val-boroPro (talabostat, PT-100), a nonselective inhibitor of post-proline cleaving serine proteases, stimulates mammalian immune systems through an unknown mechanism of action. Despite this lack of mechanistic understanding, Val-boroPro has attracted significant interest as a potential anticancer a...

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Publicado no:Nat Chem Biol
Main Authors: Okondo, Marian C., Johnson, Darren C., Sridharan, Ramya, Go, Eun Bin, Chui, Ashley J., Wang, Mitchell S., Poplawski, Sarah E., Wu, Wengen, Liu, Yuxin, Lai, Jack H., Sanford, David G., Arciprete, Michael O., Golub, Todd R., Bachovchin, William W., Bachovchin, Daniel A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5477230/
https://ncbi.nlm.nih.gov/pubmed/27820798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.2229
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