DPP8/9 inhibitor-induced pyroptosis for treatment of acute myeloid leukemia

Small-molecule inhibitors of the serine dipeptidases DPP8 and DPP9 (DPP8/9) induce a lytic form of cell death called pyroptosis in mouse and human monocytes and macrophages(1,2). In mouse myeloid cells, Dpp8/9 inhibition activates the inflammasome sensor Nlrp1b, which in turn activates pro-caspase-1...

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Bibliographic Details
Published in:Nat Med
Main Authors: Johnson, Darren C., Taabazuing, Cornelius Y., Okondo, Marian C., Chui, Ashley J., Rao, Sahana D., Brown, Fiona C., Reed, Casie, Peguero, Elizabeth, de Stanchina, Elisa, Kentsis, Alex, Bachovchin, Daniel A.
Format: Artigo
Language:Inglês
Published: 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6082709/
https://ncbi.nlm.nih.gov/pubmed/29967349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41591-018-0082-y
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