DPP9’s Enzymatic Activity and Not Its Binding to CARD8 Inhibits Inflammasome Activation

[Image: see text] Inflammasomes are multiprotein complexes formed in response to pathogens. NLRP1 and CARD8 are related proteins that form inflammasomes, but the pathogen-associated signal(s) and the molecular mechanisms controlling their activation have not been established. Inhibitors of the serin...

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Veröffentlicht in:ACS Chem Biol
Hauptverfasser: Griswold, Andrew R., Ball, Daniel P., Bhattacharjee, Abir, Chui, Ashley J., Rao, Sahana D., Taabazuing, Cornelius Y., Bachovchin, Daniel A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2019
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6862324/
https://ncbi.nlm.nih.gov/pubmed/31525884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.9b00462
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