DPP8/9 inhibitors activate the CARD8 inflammasome in resting lymphocytes

Canonical inflammasomes are innate immune signaling platforms that are formed in response to intracellular pathogen-associated signals and trigger caspase-1-dependent pyroptosis. Inflammasome formation and signaling is thought to mainly occur in myeloid cells, and in particular monocytes and macroph...

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Publicado en:Cell Death Dis
Autores principales: Johnson, Darren C., Okondo, Marian C., Orth, Elizabeth L., Rao, Sahana D., Huang, Hsin-Che, Ball, Daniel P., Bachovchin, Daniel A.
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7428001/
https://ncbi.nlm.nih.gov/pubmed/32796818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-02865-4
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