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DPP8/9 inhibitors activate the CARD8 inflammasome in resting lymphocytes

Canonical inflammasomes are innate immune signaling platforms that are formed in response to intracellular pathogen-associated signals and trigger caspase-1-dependent pyroptosis. Inflammasome formation and signaling is thought to mainly occur in myeloid cells, and in particular monocytes and macroph...

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Bibliografiske detaljer
Udgivet i:Cell Death Dis
Main Authors: Johnson, Darren C., Okondo, Marian C., Orth, Elizabeth L., Rao, Sahana D., Huang, Hsin-Che, Ball, Daniel P., Bachovchin, Daniel A.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7428001/
https://ncbi.nlm.nih.gov/pubmed/32796818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-02865-4
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