Caspase-1 interdomain linker cleavage is required for pyroptosis

Pathogen-related signals induce a number of cytosolic pattern-recognition receptors (PRRs) to form canonical inflammasomes, which activate pro-caspase-1 and trigger pyroptotic cell death. All well-studied inflammasome-forming PRRs oligomerize with the adapter protein ASC (apoptosis-associated speck-...

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Vydáno v:Life Sci Alliance
Hlavní autoři: Ball, Daniel P, Taabazuing, Cornelius Y, Griswold, Andrew R, Orth, Elizabeth L, Rao, Sahana D, Kotliar, Ilana B, Vostal, Lauren E, Johnson, Darren C, Bachovchin, Daniel A
Médium: Artigo
Jazyk:Inglês
Vydáno: Life Science Alliance LLC 2020
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7025033/
https://ncbi.nlm.nih.gov/pubmed/32051255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.26508/lsa.202000664
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