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N-terminal degradation activates the NLRP1B inflammasome
Intracellular pathogens and danger signals trigger the formation of inflammasomes, which activate inflammatory caspases and induce pyroptosis. The anthrax lethal factor metalloprotease and small-molecule DPP8/9 inhibitors both activate the NLRP1B inflammasome, but the molecular mechanism of NLRP1B a...
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| Publicat a: | Science |
|---|---|
| Autors principals: | , , , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2019
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6610862/ https://ncbi.nlm.nih.gov/pubmed/30872531 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aau1208 |
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