N-terminal degradation activates the NLRP1B inflammasome

Intracellular pathogens and danger signals trigger the formation of inflammasomes, which activate inflammatory caspases and induce pyroptosis. The anthrax lethal factor metalloprotease and small-molecule DPP8/9 inhibitors both activate the NLRP1B inflammasome, but the molecular mechanism of NLRP1B a...

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Bibliographic Details
Published in:Science
Main Authors: Chui, Ashley J., Okondo, Marian C., Rao, Sahana D., Gai, Kuo, Griswold, Andrew R., Johnson, Darren C., Ball, Daniel P., Taabazuing, Cornelius Y., Orth, Elizabeth L., Vittimberga, Brooke A., Bachovchin, Daniel A.
Format: Artigo
Language:Inglês
Published: 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6610862/
https://ncbi.nlm.nih.gov/pubmed/30872531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aau1208
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