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Superfamily-wide portrait of serine hydrolase inhibition achieved by library-versus-library screening
Serine hydrolases (SHs) are one of the largest and most diverse enzyme classes in mammals. They play fundamental roles in virtually all physiological processes and are targeted by drugs to treat diseases such as diabetes, obesity, and neurodegenerative disorders. Despite this, we lack biological und...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3000285/ https://ncbi.nlm.nih.gov/pubmed/21084632 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1011663107 |
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