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Superfamily-wide portrait of serine hydrolase inhibition achieved by library-versus-library screening

Serine hydrolases (SHs) are one of the largest and most diverse enzyme classes in mammals. They play fundamental roles in virtually all physiological processes and are targeted by drugs to treat diseases such as diabetes, obesity, and neurodegenerative disorders. Despite this, we lack biological und...

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Main Authors: Bachovchin, Daniel A., Ji, Tianyang, Li, Weiwei, Simon, Gabriel M., Blankman, Jacqueline L., Adibekian, Alexander, Hoover, Heather, Niessen, Sherry, Cravatt, Benjamin F.
פורמט: Artigo
שפה:Inglês
יצא לאור: National Academy of Sciences 2010
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3000285/
https://ncbi.nlm.nih.gov/pubmed/21084632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1011663107
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