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Click-generated triazole ureas as ultrapotent, in vivo-active serine hydrolase inhibitors

Serine hydrolases (SHs) are a diverse enzyme class representing > 1% of all human proteins. The biological functions for most SHs remain poorly characterized due to a lack of selective inhibitors to probe their activity in living systems. Here, we show that a substantial number of SHs can be irre...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Adibekian, Alexander, Martin, Brent R., Wang, Chu, Hsu, Ku-Lung, Bachovchin, Daniel A., Niessen, Sherry, Hoover, Heather, Cravatt, Benjamin F.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: 2011
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC3118922/
https://ncbi.nlm.nih.gov/pubmed/21572424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.579
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