Discovery and Optimization of Piperidyl-1,2,3-Triazole Ureas as Potent, Selective, and In Vivo-Active Inhibitors of Alpha/Beta-Hydrolase Domain Containing 6 (ABHD6)

Alpha/beta-hydrolase domain containing 6 (ABHD6) is a transmembrane serine hydrolase that hydrolyzes the endogenous cannabinoid 2-arachidonoylglycerol (2-AG) to regulate certain forms of cannabinoid receptor-dependent signaling in the nervous system. The full spectrum of ABHD6 metabolic activities a...

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Detalhes bibliográficos
Main Authors: Hsu, Ku-Lung, Tsuboi, Katsunori, Chang, Jae Won, Whitby, Landon R., Speers, Anna E., Pugh, Holly, Cravatt, Benjamin F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3987869/
https://ncbi.nlm.nih.gov/pubmed/24152295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm400899c
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