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DAGLβ Inhibition Perturbs a Lipid Network Involved in Macrophage Inflammatory Responses
The endocannabinoid 2-arachidonoylglycerol (2-AG) is biosynthesized by diacylglycerol lipases DAGLα and DAGLβ. Chemical probes to perturb DAGLs are needed to characterize endocannabinoid function in biological processes. Here, we report a series of in vivo-active 1,2,3-triazole urea inhibitors, alon...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3513945/ https://ncbi.nlm.nih.gov/pubmed/23103940 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.1105 |
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