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DAGLβ Inhibition Perturbs a Lipid Network Involved in Macrophage Inflammatory Responses

The endocannabinoid 2-arachidonoylglycerol (2-AG) is biosynthesized by diacylglycerol lipases DAGLα and DAGLβ. Chemical probes to perturb DAGLs are needed to characterize endocannabinoid function in biological processes. Here, we report a series of in vivo-active 1,2,3-triazole urea inhibitors, alon...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Hsu, Ku-Lung, Tsuboi, Katsunori, Adibekian, Alexander, Pugh, Holly, Masuda, Kim, Cravatt, Benjamin F.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: 2012
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC3513945/
https://ncbi.nlm.nih.gov/pubmed/23103940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.1105
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