Competitive Activity-Based Protein Profiling Identifies Aza-β-Lactams as a Versatile Chemotype for Serine Hydrolase Inhibition

Serine hydrolases are one of the largest and most diverse enzyme classes in Nature. Most serine hydrolases lack selective inhibitors, which are needed for assigning functions to these enzymes. We recently discovered a set of aza-β-lactams (ABLs) that act as potent and selective inhibitors of the mam...

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Main Authors: Zuhl, Andrea M., Mohr, Justin T., Bachovchin, Daniel A., Niessen, Sherry, Hsu, Ku-Lung, Berlin, Jacob M., Dochnahl, Maximilian, López-Alberca, María P., Fu, Gregory C., Cravatt, Benjamin F.
Format: Artigo
Jezik:Inglês
Izdano: 2012
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3326416/
https://ncbi.nlm.nih.gov/pubmed/22400490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja300799t
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