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Click-generated triazole ureas as ultrapotent, in vivo-active serine hydrolase inhibitors
Serine hydrolases (SHs) are a diverse enzyme class representing > 1% of all human proteins. The biological functions for most SHs remain poorly characterized due to a lack of selective inhibitors to probe their activity in living systems. Here, we show that a substantial number of SHs can be irre...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3118922/ https://ncbi.nlm.nih.gov/pubmed/21572424 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.579 |
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