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Selectivity of Inhibitors of Endocannabinoid Biosynthesis Evaluated by Activity-Based Protein Profiling

The endocannabinoid 2-arachidonoylglycerol (2-AG) has been implicated as a key retrograde mediator in the nervous system based on pharmacological studies using inhibitors of the 2-AG biosynthetic enzymes diacyglycerol lipase α and β (DAGL- α/β). Here, we show by competitive activity-based protein pr...

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Sonraí Bibleagrafaíochta
Main Authors: Hoover, Heather S., Blankman, Jacqueline L., Niessen, Sherry, Cravatt, Benjamin F.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2008
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2634297/
https://ncbi.nlm.nih.gov/pubmed/18657971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2008.06.091
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