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α-Lytic protease can exist in two separately stable conformations with different His(57) mobilities and catalytic activities

α-Lytic protease is a bacterial serine protease widely studied as a model system of enzyme catalysis. Here we report that lyophilization induces a structural change in the enzyme that is not reversed by redissolution in water. The structural change reduces the mobility of the active-site histidine r...

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Detalhes bibliográficos
Main Authors: Haddad, Kristin Coffman, Sudmeier, James L., Bachovchin, Daniel A., Bachovchin, William W.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC545854/
https://ncbi.nlm.nih.gov/pubmed/15657134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0409279102
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