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Unusual (1)H NMR chemical shifts support (His) C(ɛ)(1)—H⋅⋅⋅O⩵C H-bond: Proposal for reaction-driven ring flip mechanism in serine protease catalysis
(13)C-selective NMR, combined with inhibitor perturbation experiments, shows that the C(ɛ)(1)—H proton of the catalytic histidine in resting α-lytic protease and subtilisin BPN′ resonates, when protonated, at 9.22 ppm and 9.18 ppm, respectively, which is outside the normal range for such protons and...
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| Main Authors: | , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
The National Academy of Sciences
2000
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC27031/ https://ncbi.nlm.nih.gov/pubmed/10984533 |
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