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Substrate-Free High-Throughput Screening Identifies Selective Inhibitors for Uncharacterized Enzymes

Target-based high-throughput screening (HTS) is essential for the discovery of small-molecule modulators of proteins. Typical screening methods for enzymes rely on extensively tailored substrate assays, which are not available for targets of poorly characterized biochemical activity. Here, we report...

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Detalhes bibliográficos
Main Authors: Bachovchin, Daniel A., Brown, Steven J., Rosen, Hugh, Cravatt, Benjamin F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2709489/
https://ncbi.nlm.nih.gov/pubmed/19329999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.1531
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