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A high throughput assay to identify substrate-selective inhibitors of the ERK protein kinases
Extracellular signal-regulated kinases 1 and 2 (ERK1/2) phosphorylate a variety of substrates important for survival and proliferation, and their activity is frequently deregulated in tumors. ERK pathway inhibitors have shown clinical efficacy as anti-cancer drugs, but most patients eventually relap...
שמור ב:
| הוצא לאור ב: | Biochem Pharmacol |
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| Main Authors: | , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
2017
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5678991/ https://ncbi.nlm.nih.gov/pubmed/28647489 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2017.06.127 |
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