Confirming Target Engagement for Reversible Inhibitors In Vivo by Kinetically Tuned Activity-Based Probes

The development of small-molecule inhibitors for perturbing enzyme function requires assays to confirm that the inhibitors interact with their enzymatic targets in vivo. Determining target engagement in vivo can be particularly challenging for poorly characterized enzymes that lack known biomarkers...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Adibekian, Alexander, Martin, Brent R., Chang, Jae Won, Hsu, Ku-Lung, Tsuboi, Katsunori, Bachovchin, Daniel A., Speers, Anna E., Brown, Steven J., Spicer, Timothy, Fernandez-Vega, Virneliz, Ferguson, Jill, Hodder, Peter S., Rosen, Hugh, Cravatt, Benjamin F.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3392194/
https://ncbi.nlm.nih.gov/pubmed/22690931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja303400u
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker