Selective inhibitors and tailored activity probes for lipoprotein-associated phospholipase A(2)

Lipoprotein-associated phospholipase A(2) (Lp-PLA(2) or PLA2G7) binds to low-density lipoprotein (LDL) particles, where it is thought to hydrolyze oxidatively truncated phospholipids. Lp-PLA(2) has also been implicated as a pro-tumorigenic enzyme in human prostate cancer. Several inhibitors of Lp-PL...

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Detalhes bibliográficos
Main Authors: Nagano, Joseph M. G., Hsu, Ku-Lung, Whitby, Landon R., Niphakis, Micah J., Speers, Anna E., Brown, Steven J., Spicer, Timothy, Fernandez-Vega, Virneliz, Ferguson, Jill, Hodder, Peter, Srinivasan, Prabhavathi, Gonzalez, Tara D., Rosen, Hugh, Bahnson, Brian J., Cravatt, Benjamin F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3549684/
https://ncbi.nlm.nih.gov/pubmed/23260346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2012.11.061
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