A highly selective, reversible inhibitor identified by comparative chemoproteomics modulates diacylglycerol lipase activity in neurons

Diacylglycerol lipase (DAGL)-α and -β are enzymes responsible for the biosynthesis of the endocannabinoid 2-arachidonoylglycerol (2-AG). Selective and reversible inhibitors are required to study the function of DAGLs in neuronal cells in an acute and temporal fashion, but they are currently lacking....

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Am Chem Soc
Prif Awduron: Baggelaar, Marc P., Chameau, Pascal J. P., Kantae, Vasudev, Hummel, Jessica, Hsu, Ku-Lung, Janssen, Freek, van der Wel, Tom, Soethoudt, Marjolein, Deng, Hui, den Dulk, Hans, Allarà, Marco, Florea, Bogdan I., Di Marzo, Vincenzo, Wadman, Wytse J., Kruse, Chris G., Overkleeft, Herman S., Hankemeier, Thomas, Werkman, Taco R., Cravatt, Benjamin F., van der Stelt, Mario
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2015
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4773911/
https://ncbi.nlm.nih.gov/pubmed/26083464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.5b04883
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