A highly selective, reversible inhibitor identified by comparative chemoproteomics modulates diacylglycerol lipase activity in neurons

Diacylglycerol lipase (DAGL)-α and -β are enzymes responsible for the biosynthesis of the endocannabinoid 2-arachidonoylglycerol (2-AG). Selective and reversible inhibitors are required to study the function of DAGLs in neuronal cells in an acute and temporal fashion, but they are currently lacking....

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Publicado no:J Am Chem Soc
Main Authors: Baggelaar, Marc P., Chameau, Pascal J. P., Kantae, Vasudev, Hummel, Jessica, Hsu, Ku-Lung, Janssen, Freek, van der Wel, Tom, Soethoudt, Marjolein, Deng, Hui, den Dulk, Hans, Allarà, Marco, Florea, Bogdan I., Di Marzo, Vincenzo, Wadman, Wytse J., Kruse, Chris G., Overkleeft, Herman S., Hankemeier, Thomas, Werkman, Taco R., Cravatt, Benjamin F., van der Stelt, Mario
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4773911/
https://ncbi.nlm.nih.gov/pubmed/26083464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.5b04883
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