Chiral disubstituted piperidinyl ureas: a class of dual diacylglycerol lipase-α and ABHD6 inhibitors

Inhibitors of diacylglycerol lipases and α,β-hydrolase domain containing protein 6 (ABHD6) are potential leads for the development of therapeutic agents for metabolic and neurodegenerative disorders. Here, we report the enantioselective synthesis and structure activity relationships of triazole urea...

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Dettagli Bibliografici
Pubblicato in:Medchemcomm
Autori principali: Deng, Hui, van der Wel, Tom, van den Berg, Richard J. B. H. N., van den Nieuwendijk, Adrianus M. C. H., Janssen, Freek J., Baggelaar, Marc P., Overkleeft, Hermen S., van der Stelt, Mario
Natura: Artigo
Lingua:Inglês
Pubblicazione: Royal Society of Chemistry 2017
Soggetti:
Chemistry
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6071720/
https://ncbi.nlm.nih.gov/pubmed/30108813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7md00029d
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