Chiral disubstituted piperidinyl ureas: a class of dual diacylglycerol lipase-α and ABHD6 inhibitors

Inhibitors of diacylglycerol lipases and α,β-hydrolase domain containing protein 6 (ABHD6) are potential leads for the development of therapeutic agents for metabolic and neurodegenerative disorders. Here, we report the enantioselective synthesis and structure activity relationships of triazole urea...

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Detalhes bibliográficos
Publicado no:Medchemcomm
Main Authors: Deng, Hui, van der Wel, Tom, van den Berg, Richard J. B. H. N., van den Nieuwendijk, Adrianus M. C. H., Janssen, Freek J., Baggelaar, Marc P., Overkleeft, Hermen S., van der Stelt, Mario
Formato: Artigo
Idioma:Inglês
Publicado em: Royal Society of Chemistry 2017
Assuntos:
Chemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6071720/
https://ncbi.nlm.nih.gov/pubmed/30108813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7md00029d
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