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A natural substrate-based fluorescence assay for inhibitor screening on diacylglycerol lipase α
The endocannabinoid 2-arachidonoylglycerol (2-AG) is predominantly biosynthesized by sn-1-diacylglycerol lipase α (DAGL-α) in the CNS. Selective inhibitors of DAGL-α will provide valuable insights in the role of 2-AG in endocannabinoid signaling processes and are potential therapeutics for the treat...
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| Опубликовано в: : | J Lipid Res |
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| Главные авторы: | , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
The American Society for Biochemistry and Molecular Biology
2015
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4373749/ https://ncbi.nlm.nih.gov/pubmed/25684760 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.D056390 |
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