Rapid and profound rewiring of brain lipid signaling networks by acute diacylglycerol lipase inhibition

Diacylglycerol lipases (DAGLα and DAGLβ) convert diacylglycerol to the endocannabinoid 2-arachidonoylglycerol. Our understanding of DAGL function has been hindered by a lack of chemical probes that can perturb these enzymes in vivo. Here, we report a set of centrally active DAGL inhibitors and a str...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Ogasawara, Daisuke, Deng, Hui, Viader, Andreu, Baggelaar, Marc P., Breman, Arjen, den Dulk, Hans, van den Nieuwendijk, Adrianus M. C. H., Soethoudt, Marjolein, van der Wel, Tom, Zhou, Juan, Overkleeft, Herman S., Sanchez-Alavez, Manuel, Mori, Simone, Nguyen, William, Conti, Bruno, Liu, Xiaojie, Chen, Yao, Liu, Qing-song, Cravatt, Benjamin F., van der Stelt, Mario
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4711871/
https://ncbi.nlm.nih.gov/pubmed/26668358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1522364112
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