Model building and refinement of a natively glycosylated HIV-1 Env protein by high-resolution cryoEM

Por Lee, Jeong Hyun, de Val, Natalia, Lyumkis, Dmitry, Ward, Andrew B.
Publicado no Structure (2015)

Well-Ordered Trimeric HIV-1 Subtype B and C Soluble Spike Mimetics Generated by Negative Selection Display Native-like Properties

Por Guenaga, Javier, de Val, Natalia, Tran, Karen, Feng, Yu, Satchwell, Karen, Ward, Andrew B., Wyatt, Richard T.
Publicado no PLoS Pathog (2015)

Structure-Guided Redesign Increases the Propensity of HIV Env To Generate Highly Stable Soluble Trimers

Por Guenaga, Javier, Dubrovskaya, Viktoriya, de Val, Natalia, Sharma, Shailendra K., Carrette, Barbara, Ward, Andrew B., Wyatt, Richard T.
Publicado no J Virol (2016)

Native cysteine residues are dispensable for the structure and function of all five yeast mitotic septins

Por de Val, Natalia, McMurray, Michael A., Lam, Lisa H., Hsiung, Chris C.-S., Bertin, Aurélie, Nogales, Eva, Thorner, Jeremy
Publicado em 2013

Cleavage-independent HIV-1 Env trimers engineered as soluble native spike mimetics for vaccine design

Por Sharma, Shailendra Kumar, de Val, Natalia, Bale, Shridhar, Guenaga, Javier, Tran, Karen, Feng, Yu, Dubrovskaya, Viktoriya, Ward, Andrew B., Wyatt, Richard T.
Publicado no Cell Rep (2015)

Targeted N-glycan deletion at the receptor-binding site retains HIV Env NFL trimer integrity and accelerates the elicited antibody response

Por Dubrovskaya, Viktoriya, Guenaga, Javier, de Val, Natalia, Wilson, Richard, Feng, Yu, Movsesyan, Arlette, Karlsson Hedestam, Gunilla B., Ward, Andrew B., Wyatt, Richard T.
Publicado no PLoS Pathog (2017)

Glycine Substitution at Helix-to-Coil Transitions Facilitates the Structural Determination of a Stabilized Subtype C HIV Envelope Glycoprotein

Por Guenaga, Javier, Garces, Fernando, de Val, Natalia, Stanfield, Robyn L., Dubrovskaya, Viktoriya, Higgins, Brett, Carrette, Barbara, Ward, Andrew B., Wilson, Ian A., Wyatt, Richard T.
Publicado no Immunity (2017)

Thermostability of Well-Ordered HIV Spikes Correlates with the Elicitation of Autologous Tier 2 Neutralizing Antibodies

Por Feng, Yu, Tran, Karen, Bale, Shridhar, Kumar, Shailendra, Guenaga, Javier, Wilson, Richard, de Val, Natalia, Arendt, Heather, DeStefano, Joanne, Ward, Andrew B., Wyatt, Richard T.
Publicado no PLoS Pathog (2016)

Uncleaved prefusion-optimized gp140 trimers derived from analysis of HIV-1 envelope metastability

Por Kong, Leopold, He, Linling, de Val, Natalia, Vora, Nemil, Morris, Charles D., Azadnia, Parisa, Sok, Devin, Zhou, Bin, Burton, Dennis R., Ward, Andrew B., Wilson, Ian A., Zhu, Jiang
Publicado no Nat Commun (2016)

Vaccine-elicited primate antibodies use a distinct approach to the HIV-1 primary receptor binding site informing vaccine redesign

Por Tran, Karen, Poulsen, Christian, Guenaga, Javier, de Val, Natalia, Wilson, Richard, Sundling, Christopher, Li, Yuxing, Stanfield, Robyn L., Wilson, Ian A., Ward, Andrew B., Karlsson Hedestam, Gunilla B., Wyatt, Richard T.
Publicado em 2014

Murine Anti-vaccinia Virus D8 Antibodies Target Different Epitopes and Differ in Their Ability to Block D8 Binding to CS-E

Por Matho, Michael H., de Val, Natalia, Miller, Gregory M., Brown, Joshua, Schlossman, Andrew, Meng, Xiangzhi, Crotty, Shane, Peters, Bjoern, Xiang, Yan, Hsieh-Wilson, Linda C., Ward, Andrew B., Zajonc, Dirk M.
Publicado no PLoS Pathog (2014)

Cryo-EM structure of a fully glycosylated soluble cleaved HIV-1 Env trimer

Por Lyumkis, Dmitry, Julien, Jean-Philippe, de Val, Natalia, Cupo, Albert, Potter, Clinton S., Klasse, Per Johan, Burton, Dennis R., Sanders, Rogier W., Moore, John P., Carragher, Bridget, Wilson, Ian A., Ward, Andrew B.
Publicado em 2013

Open and Closed Structures Reveal Allostery and Pliability in the HIV-1 Envelope Spike

Por Ozorowski, Gabriel, Pallesen, Jesper, de Val, Natalia, Lyumkis, Dmitry, Cottrell, Christopher A., Torres, Jonathan L., Copps, Jeffrey, Stanfield, Robyn L., Cupo, Albert, Pugach, Pavel, Moore, John P., Wilson, Ian A., Ward, Andrew B.
Publicado no Nature (2017)

Presenting native-like trimeric HIV-1 antigens with self-assembling nanoparticles

Por He, Linling, de Val, Natalia, Morris, Charles D., Vora, Nemil, Thinnes, Therese C., Kong, Leopold, Azadnia, Parisa, Sok, Devin, Zhou, Bin, Burton, Dennis R., Wilson, Ian A, Nemazee, David, Ward, Andrew B., Zhu, Jiang
Publicado no Nat Commun (2016)

Hidden Lineage Complexity of Glycan-Dependent HIV-1 Broadly Neutralizing Antibodies Uncovered by Digital Panning and Native-Like gp140 Trimer

Por He, Linling, Lin, Xiaohe, de Val, Natalia, Saye-Francisco, Karen L., Mann, Colin J., Augst, Ryan, Morris, Charles D., Azadnia, Parisa, Zhou, Bin, Sok, Devin, Ozorowski, Gabriel, Ward, Andrew B., Burton, Dennis R., Zhu, Jiang
Publicado no Front Immunol (2017)

Affinity maturation of a potent family of HIV antibodies is primarily focused on accommodating or avoiding glycans

Por Garces, Fernando, Lee, Jeong Hyun, de Val, Natalia, de la Pena, Alba Torrents, Kong, Leopold, Puchades, Cristina, Hua, Yuanzi, Stanfield, Robyn L., Burton, Dennis R., Moore, John P., Sanders, Rogier W., Ward, Andrew B., Wilson, Ian A.
Publicado no Immunity (2015)

Structures of Ebola Virus GP and sGP in Complex with Therapeutic Antibodies

Por Pallesen, Jesper, Murin, Charles D., de Val, Natalia, Cottrell, Christopher A., Hastie, Kathryn M., Turner, Hannah L., Fusco, Marnie L., Flyak, Andrew I., Zeitlin, Larry, Crowe, James E., Andersen, Kristian G., Saphire, Erica Ollmann, Ward, Andrew B.
Publicado no Nat Microbiol (2016)

Chemical Cross-Linking Stabilizes Native-Like HIV-1 Envelope Glycoprotein Trimer Antigens

Por Schiffner, Torben, de Val, Natalia, Russell, Rebecca A., de Taeye, Steven W., de la Peña, Alba Torrents, Ozorowski, Gabriel, Kim, Helen J., Nieusma, Travis, Brod, Florian, Cupo, Albert, Sanders, Rogier W., Moore, John P., Ward, Andrew B., Sattentau, Quentin J.
Publicado no J Virol (2015)

Differential Antibody Responses to Conserved HIV-1 Neutralizing Epitopes in the Context of Multivalent Scaffolds and Native-Like gp140 Trimers

Por Morris, Charles D., Azadnia, Parisa, de Val, Natalia, Vora, Nemil, Honda, Andrew, Giang, Erick, Saye-Francisco, Karen, Cheng, Yushao, Lin, Xiaohe, Mann, Colin J., Tang, Jeffrey, Sok, Devin, Burton, Dennis R., Law, Mansun, Ward, Andrew B., He, Linling, Zhu, Jiang
Publicado no mBio (2017)

Elicitation of Neutralizing Antibodies Targeting the V2 Apex of the HIV Envelope Trimer in a Wild-Type Animal Model

Por Voss, James E., Andrabi, Raiees, McCoy, Laura E., de Val, Natalia, Fuller, Roberta P., Messmer, Terrence, Su, Ching-Yao, Sok, Devin, Khan, Salar N., Garces, Fernando, Pritchard, Laura K., Wyatt, Richard T., Ward, Andrew B., Crispin, Max, Wilson, Ian A., Burton, Dennis R.
Publicado no Cell Rep (2017)