Affinity maturation of a potent family of HIV antibodies is primarily focused on accommodating or avoiding glycans

The high mannose patch on the HIV-1 Envelope (Env) glycoprotein is the epicenter for binding of the potent broadly neutralizing PGT121 family of antibodies, but strategies for generating such antibodies by vaccination have not been defined. We generated structures of inferred antibody intermediates...

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Gepubliceerd in:Immunity
Hoofdauteurs: Garces, Fernando, Lee, Jeong Hyun, de Val, Natalia, de la Pena, Alba Torrents, Kong, Leopold, Puchades, Cristina, Hua, Yuanzi, Stanfield, Robyn L., Burton, Dennis R., Moore, John P., Sanders, Rogier W., Ward, Andrew B., Wilson, Ian A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2015
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4692269/
https://ncbi.nlm.nih.gov/pubmed/26682982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2015.11.007
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