Affinity maturation of a potent family of HIV antibodies is primarily focused on accommodating or avoiding glycans

The high mannose patch on the HIV-1 Envelope (Env) glycoprotein is the epicenter for binding of the potent broadly neutralizing PGT121 family of antibodies, but strategies for generating such antibodies by vaccination have not been defined. We generated structures of inferred antibody intermediates...

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Detalhes bibliográficos
Publicado no:Immunity
Main Authors: Garces, Fernando, Lee, Jeong Hyun, de Val, Natalia, de la Pena, Alba Torrents, Kong, Leopold, Puchades, Cristina, Hua, Yuanzi, Stanfield, Robyn L., Burton, Dennis R., Moore, John P., Sanders, Rogier W., Ward, Andrew B., Wilson, Ian A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4692269/
https://ncbi.nlm.nih.gov/pubmed/26682982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2015.11.007
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