Affinity maturation of a potent family of HIV antibodies is primarily focused on accommodating or avoiding glycans

The high mannose patch on the HIV-1 Envelope (Env) glycoprotein is the epicenter for binding of the potent broadly neutralizing PGT121 family of antibodies, but strategies for generating such antibodies by vaccination have not been defined. We generated structures of inferred antibody intermediates...

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發表在:Immunity
Main Authors: Garces, Fernando, Lee, Jeong Hyun, de Val, Natalia, de la Pena, Alba Torrents, Kong, Leopold, Puchades, Cristina, Hua, Yuanzi, Stanfield, Robyn L., Burton, Dennis R., Moore, John P., Sanders, Rogier W., Ward, Andrew B., Wilson, Ian A.
格式: Artigo
語言:Inglês
出版: 2015
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4692269/
https://ncbi.nlm.nih.gov/pubmed/26682982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2015.11.007
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