A potent and broad neutralizing antibody recognizes and penetrates the HIV glycan shield

The HIV envelope (Env) protein gp120 is protected from antibody recognition by a dense glycan shield. However, several of the recently identified PGT broadly neutralizing antibodies appear to interact directly with the HIV glycan coat. Crystal structures of Fabs PGT 127 and 128 with Man(9) at 1.65 a...

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Hauptverfasser: Pejchal, Robert, Doores, Katie J., Walker, Laura M., Khayat, Reza, Huang, Po-Ssu, Wang, Sheng-Kai, Stanfield, Robyn L., Julien, Jean-Philippe, Ramos, Alejandra, Crispin, Max, Depetris, Rafael, Katpally, Umesh, Marozsan, Andre, Cupo, Albert, Maloveste, Sebastien, Liu, Yan, McBride, Ryan, Ito, Yukishige, Sanders, Rogier W., Ogohara, Cassandra, Paulson, James C., Feizi, Ten, Scanlan, Christopher N., Wong, Chi-Huey, Moore, John P., Olson, William C., Ward, Andrew B., Poignard, Pascal, Schief, William R., Burton, Dennis R., Wilson, Ian A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3280215/
https://ncbi.nlm.nih.gov/pubmed/21998254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1213256
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