Complete epitopes for vaccine design derived from a crystal structure of the broadly neutralizing antibodies PGT128 and 8ANC195 in complex with an HIV-1 Env trimer

The HIV-1 envelope gp160 glycoprotein (Env) is a trimer of gp120 and gp41 heterodimers that mediates cell entry and is the primary target of the humoral immune response. Broadly neutralizing antibodies (bNAbs) to HIV-1 have revealed multiple epitopes or sites of vulnerability, but mapping of most of...

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Detalhes bibliográficos
Publicado no:Acta Crystallogr D Biol Crystallogr
Main Authors: Kong, Leopold, Torrents de la Peña, Alba, Deller, Marc C., Garces, Fernando, Sliepen, Kwinten, Hua, Yuanzi, Stanfield, Robyn L., Sanders, Rogier W., Wilson, Ian A.
Formato: Artigo
Idioma:Inglês
Publicado em: International Union of Crystallography 2015
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4601371/
https://ncbi.nlm.nih.gov/pubmed/26457433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1399004715013917
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