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Immunosilencing a Highly Immunogenic Protein Trimerization Domain

Many therapeutic proteins and protein subunit vaccines contain heterologous trimerization domains, such as the widely used GCN4-based isoleucine zipper (IZ) and the T4 bacteriophage fibritin foldon (Fd) trimerization domains. We found that these domains induced potent anti-IZ or anti-Fd antibody res...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Autores principales: Sliepen, Kwinten, van Montfort, Thijs, Melchers, Mark, Isik, Gözde, Sanders, Rogier W.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2015
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4367253/
https://ncbi.nlm.nih.gov/pubmed/25635058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.620534
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