Presenting native-like HIV-1 envelope trimers on ferritin nanoparticles improves their immunogenicity

BACKGROUND: Presenting vaccine antigens in particulate form can improve their immunogenicity by enhancing B cell activation. FINDINGS: We describe ferritin-based protein nanoparticles that display multiple copies of native-like HIV-1 envelope glycoprotein trimers (BG505 SOSIP.664). Trimer-bearing na...

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Detalhes bibliográficos
Publicado no:Retrovirology
Main Authors: Sliepen, Kwinten, Ozorowski, Gabriel, Burger, Judith A., van Montfort, Thijs, Stunnenberg, Melissa, LaBranche, Celia, Montefiori, David C., Moore, John P., Ward, Andrew B., Sanders, Rogier W.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Short Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4583754/
https://ncbi.nlm.nih.gov/pubmed/26410741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12977-015-0210-4
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