Enhanced Immunogenicity of HIV-1 Envelope gp140 Proteins Fused to APRIL

Current HIV-1 vaccines based on the HIV-1 envelope glycoprotein spike (Env), the only relevant target for broadly neutralizing antibodies, are unable to induce protective immunity. Env immunogenicity can be enhanced by fusion to costimulatory molecules involved in B cell activation, such as APRIL an...

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Bibliografiske detaljer
Main Authors: Isik, Gözde, Sliepen, Kwinten, van Montfort, Thijs, Sanders, Rogier W.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2014
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4172553/
https://ncbi.nlm.nih.gov/pubmed/25247707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0107683
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