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Immunosilencing a Highly Immunogenic Protein Trimerization Domain
Many therapeutic proteins and protein subunit vaccines contain heterologous trimerization domains, such as the widely used GCN4-based isoleucine zipper (IZ) and the T4 bacteriophage fibritin foldon (Fd) trimerization domains. We found that these domains induced potent anti-IZ or anti-Fd antibody res...
Uloženo v:
| Vydáno v: | J Biol Chem |
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| Hlavní autoři: | , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
American Society for Biochemistry and Molecular Biology
2015
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4367253/ https://ncbi.nlm.nih.gov/pubmed/25635058 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.620534 |
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