Structure-Guided Redesign Increases the Propensity of HIV Env To Generate Highly Stable Soluble Trimers

Due to high viral diversity, an effective HIV-1 vaccine will likely require Envs derived from multiple subtypes to generate broadly neutralizing antibodies (bNAbs). Soluble Env mimics, like the native flexibly linked (NFL) and SOSIP trimers, derived from the subtype A BG505 Env, form homogeneous, st...

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Dettagli Bibliografici
Pubblicato in:J Virol
Autori principali: Guenaga, Javier, Dubrovskaya, Viktoriya, de Val, Natalia, Sharma, Shailendra K., Carrette, Barbara, Ward, Andrew B., Wyatt, Richard T.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2016
Soggetti:
Vaccines and Antiviral Agents
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4810649/
https://ncbi.nlm.nih.gov/pubmed/26719252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02652-15
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