Structure-Guided Redesign Increases the Propensity of HIV Env To Generate Highly Stable Soluble Trimers

Due to high viral diversity, an effective HIV-1 vaccine will likely require Envs derived from multiple subtypes to generate broadly neutralizing antibodies (bNAbs). Soluble Env mimics, like the native flexibly linked (NFL) and SOSIP trimers, derived from the subtype A BG505 Env, form homogeneous, st...

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Detalles Bibliográficos
Publicado en:J Virol
Main Authors: Guenaga, Javier, Dubrovskaya, Viktoriya, de Val, Natalia, Sharma, Shailendra K., Carrette, Barbara, Ward, Andrew B., Wyatt, Richard T.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2016
Assuntos:
Vaccines and Antiviral Agents
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4810649/
https://ncbi.nlm.nih.gov/pubmed/26719252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02652-15
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