Structure-Guided Redesign Increases the Propensity of HIV Env To Generate Highly Stable Soluble Trimers

Due to high viral diversity, an effective HIV-1 vaccine will likely require Envs derived from multiple subtypes to generate broadly neutralizing antibodies (bNAbs). Soluble Env mimics, like the native flexibly linked (NFL) and SOSIP trimers, derived from the subtype A BG505 Env, form homogeneous, st...

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Détails bibliographiques
Publié dans:J Virol
Auteurs principaux: Guenaga, Javier, Dubrovskaya, Viktoriya, de Val, Natalia, Sharma, Shailendra K., Carrette, Barbara, Ward, Andrew B., Wyatt, Richard T.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2016
Sujets:
Vaccines and Antiviral Agents
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4810649/
https://ncbi.nlm.nih.gov/pubmed/26719252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02652-15
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