Cleavage-independent HIV-1 Env trimers engineered as soluble native spike mimetics for vaccine design

Viral glycoproteins mediate entry by pH-activated or receptor-engaged activation and exist in metastable pre-fusogenic states that may be stabilized by directed rational design. As recently reported, the conformationally fixed HIV-1 envelope glycoprotein (Env) trimers in the pre-fusion state (SOSIP)...

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Udgivet i:Cell Rep
Main Authors: Sharma, Shailendra Kumar, de Val, Natalia, Bale, Shridhar, Guenaga, Javier, Tran, Karen, Feng, Yu, Dubrovskaya, Viktoriya, Ward, Andrew B., Wyatt, Richard T.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4637274/
https://ncbi.nlm.nih.gov/pubmed/25892233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.03.047
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